Total synthesis of cyclic peptides

We are interested in the new strategies for the synthesis of cyclic peptides, and we have recently completed the synthesis of the natural product K13 by an intramolecular Negishi reaction. This route allows a very short synthesis, because the macrocyclisation precursor is a simple tripeptide.

amino acids

Key References

Manuel Perez-Gonzalez and Richard F.W. Jackson, Chem. Commun., 2000, 2423-2424.