New catalysts using combinatorial methods

We are interested in devloping new modular ligands, which comprise a series of components, each of which can be easily varied. Such ligands can be prepared both in solution, and on the solid phase, and upon binding to a metal, produce catalytically active species. For example, the compound below which is comprised of four components (the solid support and linker, amino acid 1, amino acid 2, and an aromatic aldehyde), has proved a useful lead in the discovery of new sulfur oxidation catalysts.

New catalysts using combinatorial methods

We have also carried out collaborative work with the group of Cesare Gennari in Milan, using solution phase ligands. this work is part of a larger European Union-supported Research Training Network, coordinated by Albrecht Berkessel in Cologne.

Key References

C. Gennari, S. Ceccarelli, U. Piarulli, C.A.G.N. Montalbetti, and R.F.W. Jackson, J. Org. Chem., 1998, 63, 5312-5313.

S. Ongeri, U. Piarulli, R.F.W. Jackson and C. Gennari, Eur. J. Org. Chem., 2001, 803-807.

Stuart D. Green, Chiara Monti, Richard F.W. Jackson, Michael S. Anson and Simon J.F. Macdonald Chem. Commun., 2001, 2594-2595.