Publications 1991-2000

2000 / 1999 / 1998 / 1997 / 1996 / 1995 / 1994 / 19931992 / 1991

2000

A new route to hydrophobic amino acids using copper-promoted reactions of serine-derived organozinc reagents.

Deboves, Herve J. C.; Grabowska, Urszula; Rizzo, Adriana; Jackson, Richard F. W.

Perkin 1, 2000, 4284-4292

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Efficient synthesis of protected β-phenylethylamines, enantiomerically pure protected β-phenyl-α-benzylethylamines and β-phenyl-α-isopropylethylamines using organozinc chemistry.

Hunter, Christopher; Jackson, Richard F. W.; Rami, Harshad K.

Perkin 1, 2000, 219-223

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NMR Kinetic Studies on the Decomposition of β-Amidozinc Reagents: Optimization of Palladium-Catalyzed Cross-Coupling with Acid Chlorides.

Dexter, Charles S.; Hunter, Christopher; Jackson, Richard F. W.; Elliott, Jason

J. Org. Chem., 2000, 65, 7417-7421

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Palladium-catalyzed C-C macrocyclization of a simple tripeptide: efficient total synthesis of K-13.

Perez-Gonzalez, Manuel; Jackson, Richard F. W.

Chem. Commun., 2000, 2423-2424

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Room temperature palladium-catalyzed coupling of amino acid-derived organozinc reagents with aryl triflates.

Dexter, Charles S.; Jackson, Richard F. W.; Elliott, Jason.

Tetrahedron, 2000, 56, 4539-4540

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1999

Synthesis of enantiomerically pure β- and γ-amino acid derivatives using functionalized organozinc reagents.

Dexter, Charles S.; Jackson, Richard F. W.; Elliott, Jason.

J. Org. Chem., 1999, 64, 7579-7585

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Preparation and use of organozinc halides.

Jackson, Richard F. W.

Organozinc Reagents, OUP, 1999, 37-56


Stereoselective syntheses of protected β-hydroxy-α-amino acids using (arylthio)nitrooxiranes.

Adams, Zoe M.; Jackson, Richard F. W.; Palmer, Nicholas J.; Rami, Harshad K.; Wythes, Martin J.

Perkin 1, 1999, 937-948

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A trifunctional steroid-based scaffold for combinatorial chemistry.

Barry, John F.; Davis, Anthony P.; Perez-Payan, M. Nieves; Elsegood, Mark R. J.; Jackson, Richard F. W.; Gennari, Cesare; Piarulli, Umberto; Gude, Markus.

Tetrahedron Letters, 1999, 40, 2849-2852

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Design and synthesis of a novel cyclo-β-tetrapeptide.

Sutton, Peter W.; Bradley, Adrian; Elsegood, Mark R. J.; Farras, Jaume; Jackson, Richard F. W.; Romea, Pedro; Urpi, Felix; Vilarrasa, Jaume.

Tetrahedron Letters, 1999, 40, 2629-2632

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1998

Stereoselective epoxidation of vinyl sulfones and N-(p-tolylsulfonyl)vinylsulfoximines derived from isopropylideneglyceraldehyde: synthesis of chiral building blocks.

Briggs, Andrew D.; Jackson, Richard F. W.; Brown, Paul A.

Perkin 1, 1998, 4097-4102

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Conformational variations in vinylsulfoximines.

Briggs, Andrew D.; Clegg, William; Elsegood, Mark R. J.; Frampton, Christopher S.; Jackson, Richard F. W..

Acta Crystallographica, Section C: Crystal Structure Communications, 1998, C54(9), 1335-1341

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Concise Synthesis of Enantiomerically Pure Phenylalanine, Homophenylalanine, and Bishomophenylalanine Derivatives Using Organozinc Chemistry: NMR Studies of Amino Acid-Derived Organozinc Reagents.

Jackson, Richard F. W.; Moore, Rebecca J.; Dexter, Charles S.; Elliott, Jason; Mowbray, Charles E.

J. Org. Chem., 1998, 2, 527-550

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The development of zinc and zinc/copper reagents for the synthesis of enantiomerically pure amino acids.

Gair, Susan; Jackson, Richard F. W..

Current Organic Chemistry, 1998, 2, 527-550

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Preparation of enantiomerically enriched bromohydrins from [N-(p-tolylsulfonyl)sulfoximino]oxiranes using in situ reduction of α-bromo aldehydes.

Bailey, Peter L.; Briggs, Andrew D.; Jackson, Richard F. W.; Pietruszka, Jorg.

Perkin 1, 1998, 3359-3364

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Investigation of a New Family of Chiral Ligands for Enantioselective Catalysis via Parallel Synthesis and High-Throughput Screening.

Gennari, Cesare; Ceccarelli, Simona; Piarulli, Umberto; Montalbetti, Christian A. G. N.; Jackson, Richard F. W..

J. Org. Chem., 1998, 63, 5312-5313

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Synthesis of α-amino acids using amino acid γ-anion equivalents: synthesis of 5-oxo α-amino acids, homophenylalanine derivatives and pentenylglycines.

Jackson, Richard F. W.; Fraser, Joanne L.; Wishart, Neil; Porter, Barry; Wythes, Martin J.

Perkin 1, 1998, 1903-1912

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Efficient synthesis of β- and γ-amino acid derivatives using new functionalized zinc reagents: enhanced stability and reactivity of β-amido zinc reagents in dimethylformamide

Dexter, Charles S.; Jackson, Richard F. W..

Chem. Commun., 1998, 75-76

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1997

Reaction of thiophenol with glucal epoxides: X-ray structure of 3,4,6-tri-O-tert-butyldimethylsilyl-1-S-phenyl-1-thio-α-D-glucopyranoside.

Walford, Caroline; Jackson, Richard F. W.; Rees, Nicholas H.; Clegg, William; Heath, Sarah L.

Chem. Commun., 1997, 1855-1856

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A new approach to the synthesis of di- and tripeptides with unnatural amino acids using organozinc chemistry.

Dunn, Michael J.; Jackson, Richard F. W..

Tetrahedron, 1997, 53, 13905-13914

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Stereospecific allylation of a serine-derived zinc/copper reagent. Synthesis of substituted pipecolic acid derivatives.

Jackson, Richard F. W.; Turner, Debra; Block, Michael H.

Synlett, 19977, 789-790

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N-(2,3,5,6-Tetrachloropyrid-4-yl)cinnamide.    

Clegg, William; Elsegood, Mark R. J.; Jackson, Richard F. W.; Fraser, Joanne L.; Emsden, Lee J.

Acta Crystallographica, Section C: Crystal Structure Communications1997C53(6),  797-799

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Stereoselective synthesis of all stereoisomeric 2-amino-3-methyl-4-phenylbutanolides [Erratum to document cited in CA127:34073].

Gair, Susan; Jackson, Richard F. W.; Brown, Paul A.

Tet. Lett.199738(22), 3795

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Stereoselective synthesis of all stereoisomeric 2-amino-3-hydroxy-4-phenylbutanolides.

Gair, Susan; Jackson, Richard F. W.; Brown, Paul A.

Tet. Lett.199738(17), 3059-3062

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Carbonylative coupling of organozinc reagents in the presence and absence of aryl iodides: synthesis of unsymmetrical and symmetrical ketones. 

Jackson, Richard F. W.; Turner, Debra; Block, Michael H.

Perkin 1, 19976, 865-870

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Asymmetric epoxidation of chalcones with chirally modified lithium and magnesium tert-butyl peroxides.

Elston, Catherine L.; Jackson, Richard F. W.; Macdonald, Simon J. F.; Murray, P. John.

Angewandte Chemie, International199736(4),  410-412

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1996

Direct synthesis of metal-complexed aromatic amino acid derivatives by palladium-catalyzed coupling processes.

Jackson, Richard F. W.; Turner, Debra; Block, Michael H.

Synlett, 19969, 862-864

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Synthesis of C-linked glycosyl amino acid derivatives using organozinc reagents.

Dorgan, Brian J.; Jackson, Richard F. W.

Synlett19969, 859-861

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Stereoselective addition of organometallic reagents of N-(tosyl)vinylsulfoximines.

Jackson, Richard F. W.; Briggs, Andrew D.; Brown, Paul A.; Clegg, William; Elsegood, Mark R. J.; Frampton, Christopher.

Perkin 1199614, 1673-1682

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Stereoselective synthesis of anti-β-amino-α-hydroxy acid derivatives using nucleophilic epoxidation of 1-arylthio-1-nitroalkenes.

Ambroise, Lydia; Jackson, Richard F. W.

Tet. Lett.199637(13), 2311-14.

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1995

Carbonylative coupling of an amino acid-derived organozinc reagent with functionalized aryl iodides: synthesis of kynurenine. 

Jackson, Richard F. W.; Turner, Debra; Block, Michael H.

Chemical Communications, 199521,  2207-8.

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Two products of ring opening reactions of an arylthionitrooxirane.

Clegg, William; Dunbar, Joanna M.; Elsegood, Mark R. J.; Jackson, Richard F. W.; Palmer, Nicholas J.

Acta Crystallographica, Section C: Crystal Structure Communications, 1995C51(9), 1950-3.

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An epoxyamide.

Clegg, William; Ranelli, Massimo; Jackson, Richard F. W.

Acta Crystallographica, Section C: Crystal Structure Communications, 1995C51(8),  1604-6.

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Improved preparation of enantiomerically pure 5-oxo amino acid derivatives by palladium-catalyzed coupling reactions.

Fraser, Joanne L.; Jackson, Richard F. W.; Porter, Barry.

Synlett, 19958, 819-20.

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A New Approach to the Synthesis of β-Hydroxy-α-amino Acids Using (Arylthio)nitrooxiranes.

Jackson, Richard F. W.; Palmer, Nicholas J.; Wythes, Martin J.; Clegg, William; Elsegood, Mark R. J.

JOC, 199560(20), 6431-40.

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A new approach to the synthesis of dipeptides with unnatural amino acids using organozinc chemistry.

Dunn, Michael J.; Gomez, Sylvie; Jackson, Richard F. W.

Perkin 1, 199513, 1639-40.

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p-Nitrobenzyl trichloroacetimidate. 

Clegg, William; Pogue, Harry J.; Lowe, Mark P.; Butterfield, Ian M.; Jackson, Richard F. W.

Acta Crystallographica, Section C: Crystal Structure Communications, 1995C51(4), 741-3.

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2,6-Diphenyl-3-vinylpyridine.

Clegg, William; Hewkin, Cheryl T.; Jackson, Richard F. W.

Acta Crystallographica, Section C: Crystal Structure Communications, 1995C51(3),  525-7.

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Synthesis of Enantiomerically Pure Unsaturated α-Amino Acids Using Serine-Derived Zinc/Copper Reagents.

Dunn, Michael J.; Jackson, Richard F. W.; Pietruszka, Joerg; Turner, Debra.

JOC199560(7),  2210-15.

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Control of diastereofacial selectivity in the nucleophilic epoxidation of γ-oxygenated α,β-unsaturated sulfones.

Jackson, Richard F. W.; Standen, Stephen P.; Clegg, William.

Perkin 119952, 149-56.

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Stereocontrol in the nucleophilic epoxidation of α-(1-hydroxyalkyl)-α,β-unsaturated sulfones.

Jackson, Richard F. W.; Standen, Stephen P.; Clegg, William; McCamley, Andrew.

Perkin 119952, 141-8.

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1994

Stereoselective syntheses of protected D-threonine and L-allo-threonine.

Jackson, Richard F. W.; Palmer, Nicholas, J.; Wythes, Martin J.

Tet. Lett.199435(40), 7433-4.

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Effects of additional stereogenic centers and cation in the nucleophilic epoxidation of vinylsulfoximines with metal alkylperoxides.

Briggs, Andrew D.; Jackson, Richard F. W.; Clegg, William; Elsegood, Mark R. J.; Kelly, Josephine; Brown, Paul A.

Tet. Lett199435(37), 6945-8.

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Reduction of 4-oxo α-amino acids as a route to 4-hydroxylated α-amino acids. Concise approaches to the synthesis of clavalanine, erythro-4-hydroxyornithine and (+)-bulgecinine.

Jackson, Richard F. W.; Rettie, Alan B.; Wood, Anthony; Wythes, Martin J.

Perkin 1199413,  1719-26.

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Synthesis of protected 4-oxopipecolic acid and 4-oxolysine using a palladium-catalyzed coupling process.

Jackson, Richard F. W.; Graham, Lisa J.; Rettie, Alan B.

Tet. Lett.199435(25),  4417-18.

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An efficient and flexible route to (+)-polyoxamic acid using diastereoselective epoxidation of 1-arylthio-1-nitroalkenes.

Jackson, Richard F. W.; Palmer, Nicholas J.; Wythes, Martin J.

Chemical Communications, 19941,  95-6.

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Preparation of enantiomerically pure homophenylalanine derivatives by palladium-catalyzed coupling reactions.

Fraser, Joanne L.; Jackson, Richard F. W.; Porter, Barry.  

Synlett19945,  379-80.

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A flexible and rational synthesis of substituted triphenylenes by palladium-catalyzed cross-coupling of arylzinc halides.

Borner, Ruth C.; Jackson, Richard F. W.

Chemical Communications, 19947,  845-6.

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An enantiomerically pure 4-oxo-α-amino acid derivative. 

Clegg, William; Jackson, Richard F. W.; O'Neil, Paul A.; Wishart, Neil.

Acta Crystallographica, Section C: Crystal Structure Communications, 1994C50(6), 965-7.

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1993

Preparation of enantiomerically enriched bromohydrins by reaction of sulfoximinooxiranes with magnesium dibromide in the presence of tetrabutylammonium borohydride. 

Bailey, Peter L.; Briggs, Andrew D.; Jackson, Richard F. W.; Pietruszka, Jorg.

Tetrahedron Letters, 199334(41),  6611-14.

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Preparation of a serine-derived organozinc reagent in tetrahydrofuran: synthesis of novel, enantiomerically pure allenic, acetylenic and heteroaryl amino acids.

Dunn, Michael J.; Jackson, Richard F. W.; Pietruszka, Jorg; Wishart, Neil; Ellis, David; Wythes, Martin J.

Synlett, 19937, 499-500.

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Control of diastereoselectivity in the nucleophilic epoxidation of 1-arylthio-1-nitroalkenes: synthesis of diastereoisomerically pure γ-hydroxy threonine derivatives.     

Jackson, Richard F. W.; Kirk, Joanna M.; Palmer, Nicholas J.; Waterson, David; Wythes, Martin J.

Chemical Communications, 199311, 889-90.

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Short stereoselective synthesis of 4,5,6-trihydroxylated norleucines: an approach to the synthesis of (+)-bulgecinine.   

Jackson, Richard F. W.; Rettie, Alan B.

Tetrahedron Letters, 199334(18), 2985-6.

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Diastereoselective synthesis of cyclopropanes with multiple sulfur substitution. X-ray molecular structures of phenylsulfonyl-substituted cyclopropanes.

Bailey, Peter L.; Hewkin, Cheryl T.; Clegg, William; Jackson, Richard F. W.

Perkin 1, 19935, 577-84.

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A new α-amino acid γ-anion equivalent: direct synthesis of enantiomerically pure protected amino acids.

Jackson, Richard F. W.; Wishart, Neil; Wythes, Martin J.

Synlett, 19933, 219-20.

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Synthesis and highly diastereoselective nucleophilic epoxidation of N-(p-tolylsulfonyl)vinylsulfoximines.

Bailey, Peter L.; Clegg, William; Jackson, Richard F. W.; Meth-Cohn, Otto.

Perkin 119933, 343-50.

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1992

Reactions of a serine-derived zinc/copper reagent with tricarbonyl(cyclohexadienyl)iron salts:  synthesis of protected amino acids.

Dunn, Michael J.; Jackson, Richard F. W.; Stephenson, G. Richard.

Synlett, 199211, 905-6.

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Reaction of a serine-derived organozinc reagent with chloroformates and ethyl oxalyl chloride under palladium catalysis.  Preparation of protected (2S,6S)-4-oxo-2,6-diaminopimelic acid and (2S)-4-oxoglutamic acid.

Jackson, Richard F. W.; Wishart, Neil; Wythes, Martin J.

Chemical Communications, 199221, 1587-9.

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3-[(tert-Butyldimethylsilyloxy)methyl]-2-lithio-2-(phenylsulfonyl)oxirane as a glycidyl anion equivalent.  Preparation of terminal epoxy ketones. 

Dunn, Sara F. C.; Jackson, Richard F. W..

Perkin 1199221, 2863-70.

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Stereocontrol in nucleophilic epoxidation of α-(1-hydroxyalkyl)-α,β-unsaturated sulfones

Jackson, Richard F. W.; Standen, Stephen P.; Clegg, William; McCamley, Andrew.

Tet. Lett., 199233(41), 6197-200.

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Preparation of enantiomerically pure protected 4-oxo α-amino acids and 3-aryl α-amino acids from serine.

Jackson, Richard F. W.; Wishart, Neil; Wood, Anthony; James, Keith; Wythes, Martin J.

JOC199257(12), 3397-404.

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Preparation of 2-halo S-phenyl thioesters from 2-(phenylsulfonyl)-2-phenylthio)oxiranes.  Crystal structures of 2-phenylsulfonyloxiranes.

Hewkin, Cheryl T.; Jackson, Richard F. W.; Clegg, William.

Perkin 1199112, 3091-101.

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Preparation of enantiomerically pure protected unsaturated α-amino acids from a new serine derived zinc-copper reagent. 

Dunn, Michael J.; Jackson, Richard F. W.

Chemical Communications, 19924, 319-20.

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1991

A new method for the synthesis of α-bromoacyl silanes via ring opening of 2-(phenylsulfonyl)-2-(trimethylsilyl)oxiranes.

Hewkin, Cheryl T.; Jackson, Richard F. W.

Perkin 1199112, 3103-11.

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Control of diastereofacial selectivity in the nucleophilic epoxidation of γ-oxygenated-α,β-unsaturated sulfones.

Jackson, Richard F. W.; Standen, Stephen P.; Clegg, William.

Tet. Lett.199132(39), 5393-6.

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Nucleophilic addition-elimination reactions of N-(p-tolylsulfonyl)vinylsulfoximines: preparation of α-methylene nitriles and phosphonates.

Bailey, Peter L.; Jackson, Richard F. W.

Tet. Lett.199132(26), 3119-22.

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Phenylsulfonyloxiranes as functionalized acyl anion equivalents in organic synthesis.

Ashwell, Mark; Clegg, William; Jackson, Richard F. W.

Perkin 11991, 4, 897-908.

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